Comfort Cream

$59.00$99.00

Stop letting discomfort from joint aches slow you down. Find the balance you need to live your life on your terms, even when it’s as simple as a headache, or other chronic discomfort that affects your daily life.

Our pharmaceutical compounding doctors developed this powerful Transdermal Comfort Assist Cream that combines Active Pharmaceutical Ingredients (APIs), whole plant CBD, and a unique FDA-approved transdermal liposomal base cream known as Microsome Plus ™. The APIs in Comfort Assist Cream are absorbed through your skin and help manage discomfort where you need it most… at the site of application.

Ingredients include:

  • Reduced Pain – Curcumin to help reduce pain and inflammation
  • Anti-Inflammatory – Methylsulfonylmethane (MSM) is a potent anti-inflammatory often used for pain
  • Decreased Pain – Palmitoylethanolamide (P.E.A.) is an endocannabinoid that studies have shown to have strong activity against pain
  • Enhances Absorption – BioPerine(R) is a key ingredient that studies indicate can enhance the absorption of active ingredients
  • Find the Balance – Whole-plant CBD can increase the effectiveness of the other ingredients and assists the body in achieving homeostatic balance.
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  • Description

    Stop letting discomfort from joint aches slow you down. Find the balance you need to live your life on your terms, even when it’s as simple as a headache, or other chronic discomfort that affects your daily life.

    Our pharmaceutical compounding doctors developed this powerful Transdermal Comfort Assist Cream that combines Active Pharmaceutical Ingredients (APIs), whole plant CBD, and a unique FDA-approved transdermal liposomal base cream known as Microsome Plus ™. The APIs in Comfort Assist Cream are absorbed through your skin and help manage discomfort where you need it most… at the site of application.

    The liposomal property of Microsome PlusTM allows our combination of active ingredients to be quickly absorbed through all layers of your skin. Ingredients include:

    • Reduced Pain – Curcumin to help reduce pain and inflammation
    • Anti-Inflammatory – Methylsulfonylmethane (MSM) is a potent anti-inflammatory often used for pain
    • Decreased Pain – Palmitoylethanolamide (P.E.A.) is an endocannabinoid that studies have shown to have strong activity against pain
    • Enhances Absorption – BioPerine(R) is a key ingredient that studies indicate can enhance the absorption of active ingredients
    • Find the Balance – Whole-plant CBD can increase the effectiveness of the other ingredients and assists the body in achieving homeostatic balance.

    When applied topically, Comfort Assist transports our carefully selected APIs through all layers of the skin to deliver them to the site of pain. Microsome Plus™ is the only base cream tested and verified as being free of “impurities” and “allergens” assuring that they will not get into your body.

    Note that it isn’t the amount of CBD in the product, instead, it’s the amount reaching the site of activity that determines effectiveness.

  • What is Cannabidiol (CBD)?

    Cannabidiol (CBD) is classified as a “Phyto-cannabinoid.” This means that:

    • CBD is a molecule produced by the Cannabis plant.
    • Classified as a “Negative Allosteric Modulator” (can help to reduce overproduction of neurotransmitters – possible mechanism of action in the neurotransmission of pain signals).
    • While all PRISMM Earth products use organic, whole-plant CBD, if you hear products that use “Synthetic” and/or “Isolate” CBD, know that it does not come from nature.
    • Although psychoactive, CBD does not cause intoxication.
    • Thought to be responsible for the majority of Cannabis’ therapeutic claims.
    • Reduces undesirable effects of THC.
    • Has been shown to inhibit cancer cell growth, not kill cancer cells.
    • Activates Adenosine, Serotonin and Vanilloid receptors which explains CBD’s diverse therapeutic claims
  • What is Curcumin?

    Curcumin is the yellow pigment associated with the curry spice Turmeric, and to a lesser extent Ginger. It is a small molecule that is the prototypical 'Curcuminoid', and has effects similar to other polyphenols but unique since it is a different class of polyphenol (relative to the other classes of 'flavonoid', 'stilbene', etc.)

    What Does Curcumin Do?

    Curcumin exhibits an array of positive effects on the human body. Most notably, it is an antioxidant which can regulate metabolic reactions. The use of curcumin provides a potential remedy for joint inflammation. It lowers swelling and enables better movement and functioning at the site.

    How Does Curcumin Work?

    Subsequent to the first seminal paper published in 1949 in Nature, numerous preclinical studies have provided a solid basis for examining curcumin’s efficacy against human diseases. Common to all of these studies have been the safety, tolerability, and non-toxicity of this polyphenol, even at doses up to 8 g per day. The underlying mechanism for curcumin’s clinical efficacy seems to be modulation of numerous signaling molecules. However, because of the complex nature of the diseases, the underlying mechanism in many cases remains unclear.

    More specifically, Curcumin:

    • Alleviates Pain
    • Natural Anti-Inflammatory Agent
    • Helps Arthritic Conditions
    • Natural Bone Protective Agent
    • Prevents Cartilage Degeneration
    • Helps Arthritic Conditions
  • What is PALMITOYLETHANOLOMIDE (P.E.A.)?

    The Multiple Target Molecule - A Key Player in the Endocannabinoid System

    A unique fatty acid that can be found in eggs and a variety of plant sources, and which is also produced endogenously (within our own bodies), Palmitoyl-ethanol-amide (PEA) plays an important role in the body's systematic response to pain and inflammation.

    What Does P.E.A. Do?

    Palmitoylethanolamide (P.E.A) is an endocannabinoid-like molecule which our bodies produce as needed to deal with bodily stress, injury, or infection. It serves as part of the Endocannabinoid System (ECS): a complex communication network or cell-signaling system throughout our bodies which helps regulate a variety of functions, including protecting nerve cells, preventing arthritis and cardiovascular disease, and countering inflammation.

    Is P.E.A. a Cannabinoid?

    Although P.E.A itself shares many of the same functions as the phytocannabinoids in CBD (which is derived from cannabis oil), it is produced naturally by most mammals, so it receives a different medical and legal classification.

    Some common food sources of PEA include milk, peas, tomatoes, corn, soybeans, soy lecithin, and peanuts.

    P.E.A. and Pain:

    A 2017 meta-analysis investigated the efficacy of P.E.A for pain relief. Eight randomized controlled trials accounting for 743 patients receiving PEA and 460 patients given either placebo or no treatment showed a significantly greater pain reduction in those given PEA. Daily dosages ranged from 300mg to 1200mg, and treatment duration ranged from 10 to 180 days. Interestingly, there was no association between longer treatment durations and pain efficacy. The authors found one trial that compared 2 weeks of use of P.E.A. versus ibuprofen in 24 patients with arthritis of the TMJ (temporomandibular joint). Patients given PEA has significantly decreased pain compared to those given ibuprofen. Ibuprofen treatment also resulted in 3 patients to have the side effect of a stomachache, compared the PEA group which reported no side effects.

  • What is METHYLSULFONYLMETHANE (M.S.M.)?

    Methylsulfonylmethane (MSM) is a chemical found in green plants, animals, and humans. It can also be made in a laboratory. MSM is an excellent source of the critical mineral, Sulfur.

    Sulfur is a mineral found naturally within our bodies, as well as fruits, vegetables, milk, and animal products. But many people may not get enough sulfur in their diets, especially as they age, which can have many health detriments. Sulfur is used for many processes in the body, including helping proteins hold their shape – without this, the proteins may lose their functions.

    Sulfur can be supplemented in the body in a form known as methylsulfonylmethane, also known as MSM. This is an organic form of sulfur that can be found in foods we eat, such as raw, unprocessed milk, or you can take it as a supplement.

    How Does MSM Work?

    The sulfur mineral is a part of amino acids and actively influences the cellular functions as well as protein synthesis in your body. When a patient suffering from frequent flare-ups takes a sulfur supplement, the compounds in it can alleviate the symptoms of arthritis by stimulating the production of connective tissues and cartilage in the joints. It also acts by slowing or hindering the nerve impulses that send the pain messages to the brain.

    What is this product used for?

    Methylsulfonylmethane (MSM) is used by some people to help with pain, especially from arthritis. Others use it to help with an upset stomach or decrease muscle damage caused by exercise. Some people believe it helps to boost the immune system, fight infections, or help with allergies. It may also be used by some people to help fight skin conditions or hemorrhoids.

  • What is Bioperine?

    Bioperine is an extract obtained from black pepper fruits, and so contains as much as 95% of the extract. It is usually administered together with medications or food nutrients to increase the availability of the active substance in such food or drugs. When administered alone, it won’t have any active substance to enhance.

    What is this product used for?

    Bioperine works as that important supplement that ensures bioavailability of potent medications and food nutrients in your bloodstream, making them more available for action. Bioperine doesn’t increase the effectiveness of active substances in your foods or medications, so it’s not a bioefficacy supplement. But it makes such medications and nutrients more bioavailable so your body can effectively use them.

  • What is Microsome Plus?

    Microsome Plus is the powerful “Liposomal” base product that uniquely turns our “Topical” Cream into a “Transdermal” Cream.

    As opposed to every other “topical” cream on the market containing CBD, our TRANSDERMAL COMFORT CREAM does not rely on “passive diffusion” as a means of transporting the active ingredients through the skin. Microsome Plus uses advanced “Liposomal” technology to ACTIVELY transport ingredients through ALL layers of the skin providing maximum concentration of drugs working at the site of pain.

  • What is Liposomal Technology?

    A liposome is a closed vesicle having both lipophilic (fat loving) and hydrophilic (water loving) portions. Their size ranges from 25nm to 10mm. They are made from naturally occurring phospholipids such as Phosphatidyl Choline and Cholesterol.

    Advantages of Liposomes:

    • "Active” transportation of drug/ingredients of various sizes through both hydrophilic and lipophilic layers of the skin
    • Allow incorporation of multiple ingredients
    • Protection of drug/ingredient chemical structure during diffusion
    • Concentration of ingredients at the site of application
  • What is In Microsome Plus (TM) ?
    Water, Carthamus Tinctorius Seed Oil, Aloe Barbadensis Leaf Extract, Helianthus Annuus Seed Oil, Olea Europaea Fruit Oil, Butyrospermum Parkii Butter, Beeswax, Cetearyl Alcohol, Glyceryl Stearate, Perilla Ocymoides Seed Oil, Isopropyl Palmitate, Lysolecithin, Hydrogenated Lecithin, Perilla Ocymoides Leaf Extract, Isopropyl Myristate, Squalane, Punica Granatum Extract, Tocopheryl Acetate, Cholecalciferol, Cetyl Alcohol, Retinyl Palmitate, Vitisvinifera Seed Extract, Wheat Amino Acids, Triticum Vulgare Germ Extract, Oenothera Biennis Oil, Xanthan Gum, Phenoxyethanol

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