Liposomes are molecules consisting of an outer Lipid (Fat) Bilayer (Houses Oil-soluble Drugs])and an inner area that (Houses Solid or Water-Soluble Drugs) PRISMM Earth’s topical/transdermal creams use a Liposomal base to carry active drugs through ALL layers of the skin for maximum concentration at the site of application. This means that the topical/transdermal products produced by PRISMM Earth have the greatest Bioavailability (amount of drug reaching the target areas) in the world!
Extended-Release Cannabinoid Information:
The Doctors at PRISMM Earth understand the need for some products to be long-acting. Our Compounding Pharmacists achieve this by adding ingredients that delay the absorption of active ingredients. Delayed absorption translates into an extended duration of action.
Our sleep and pain capsules can be made to have an extended duration of action by incorporating the active ingredients into a Methylcellulose (Organic Cellulose) matrix. The uniform release is achieved by combining the Methylcellulose within a polymeric matrix (E4M) which provides a consistent release into the body.
This dosage form can help decrease the number of doses needed during a day (or night), thus improving compliance, and saving our patients money.
Troches (Lozenges) and Oral (Sublingual) Spray
The PRISMM Earth Troches are placed under the tongue for Sublingual (S.L.) absorption. A significant amount of the active ingredients is absorbed directly into the blood stream through the mucosal lining of the mouth. Under normal circumstances, only a small amount of a drug is swallowed and absorbed through the Gastro-intestinal Tract.
The benefits of this delivery system include a more rapid onset of action than through the oral route, and S.L. absorption bypasses the GI Tract thus eliminating the effects of First Pass Metabolism.
First Pass Metabolism occurs only when a drug is taken orally. The drug goes from the GI Tract directly to the Liver where it is broken down by Liver Enzymes thus reducing the amount of “active” drug up taken by the body.
Our oral spray products also have the features of:
- Sublingual absorption
- Rapid onset of action
- Bypassing “First Pass Metabolism” by the Liver
- Greater amount of active ingredients reaching the site(s) of action
- Provides a STANDARD dosing concentration (mg per spray)
In some cases, the Liver breaks down a drug into metabolites that are also active. When delta-9 Tetrahydrocannabinol (THC) is taken orally, not only is the absorption (and resulting onset of action) delayed for up to 1-2 hours, but some of the THC is metabolized from delta-9 THC to 11-OH THC (known as 11 Hydroxy THC). 11-OH THC has greater intoxicating properties than delta-9 THC!!